Ação da Substância - Cloreto de Potássio 19,1% Farmarin

Eficácia

Repõe níveis de potássio para prevenir sintomas clínicos. Estudos mostram eficácia em manter níveis adequados em hipertensos usando diuréticos e em casos de paralisia hipocalêmica.

Referências Bibliográficas

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58. Non-clinical Safety Statement – CDS Update of sections 4.6 and 5.3 Novartis Pharma AG. Basel, Switzerland. 13 Jul 07.
59. [2.5 Clinical Overview] Rationale for changes to Core Data Sheet (CDS)/Product InformationContraindications. Novartis. 08-Nov-2011
60. [2.5 Clinical Overview ] Rationale for changes to Core Data Sheet (CDS)/Product Information-Dosage and administration. Novartis. 08-Nov-2011
61. [2.5 Clinical Overview ]Rationale for changes to Core Data Sheet (CDS)/Product InformationInteractions and Clinical pharmacology. Novartis. 08-Nov-2011
62. [2.4 Non-Clinical Overview ]Rationale for changes to Core Data Sheet (CDS)/Product InformationNon-clinical safety data. Novartis. 08-Nov-2011
63. [2.5 Clinical Overview] Rationale for changes to Core Data Sheet (CDS)/Product Information- topic Overdose (Pharmacobezoar Formation). Novartis. 14-Jul-2015.

Características farmacológicas

Potássio regula impulsos nervosos, contração muscular e equilíbrio ácido-base. Sintomas de falta aparecem quando níveis sanguíneos caem abaixo de 3,5 mmol/L: fraqueza, paralisia, arritmias.

Farmacocinética

Absorção

Liberação gradual no trato digestivo quando administrado oralmente.

Eliminação

90% eliminado pelos rins em 8 horas; 98% em 24 horas.

Segurança pré-clínica

Baixa toxicidade oral. Sem evidência de risco reprodutivo ou cancerígeno relevante para humanos.